Research interests
Broadly speaking, I am interested in microbial interactions. My research interests span the fields of microbial genetics, ecology, and chemical engineering. Below I summarize the focus of my current research.
Studying microbial interactions
Microwell ArraysThis work uses microwell arrays that allow for high-throughput screening of microbe-microbe interactions and retrieval of the bacteria within microwells of interest. This retrieval capability allows follow-up genetic and phenotypic characterization of the cells within targeted microwells.
|
Photodegradable HydrogelsThis new technology allows us to efficiently screen over a hundred thousand microbial interactions in order to identify either the genetic factors influencing microbial interactions or strains influencing the performance of a focal individual.
|
Bacterial PolicingThis work looks at the dynamics between bacterial cheaters and cooperators and tries to elucidate the mechanisms that cooperators have employed as policing strategies to prevent cheaters from taking over the system.
|
Publications
Barton, I.S., Eagan, J.L., Reynolds, I., Nieves-Otero, P.A. Platt, T.G., Fuqua, C. (2021): Co-Dependent and Interdigitated: Dual Quorum Sensing Systems Regulate Conjugative Transfer of the Ti Plasmid and the At Megaplasmid in Agrobacterium tumefaciens 15955. Frontiers in Microbiology. 11:605896.
www.frontiersin.org/articles/10.3389/fmicb.2020.605896/full
Fattahi, N., Nieves-Otero, P. A., Masigol, M., van der Vlies, A. J., Jensen, R. S., Hansen, R. R., & Platt, T. G. (2020). Photodegradable Hydrogels for Rapid Screening, Isolation, and Genetic Characterization of Bacteria with Rare Phenotypes. Biomacromolecules, 21(8): 3140-3151.
https://pubs.acs.org/doi/10.1021/acs.biomac.0c00543
van der Vlies, A.J., Barua, N., Nieves-Otero, P.A., Platt, T.G. and Hansen, R.R. (2018): On Demand Release and Retrieval of Bacteria from Microwell Arrays Using Photodegradable Hydrogel Membranes. ACS Applied Bio Materials, 2 (1): 266-276.
https://pubs.acs.org/doi/pdf/10.1021/acsabm.8b00592
www.frontiersin.org/articles/10.3389/fmicb.2020.605896/full
Fattahi, N., Nieves-Otero, P. A., Masigol, M., van der Vlies, A. J., Jensen, R. S., Hansen, R. R., & Platt, T. G. (2020). Photodegradable Hydrogels for Rapid Screening, Isolation, and Genetic Characterization of Bacteria with Rare Phenotypes. Biomacromolecules, 21(8): 3140-3151.
https://pubs.acs.org/doi/10.1021/acs.biomac.0c00543
van der Vlies, A.J., Barua, N., Nieves-Otero, P.A., Platt, T.G. and Hansen, R.R. (2018): On Demand Release and Retrieval of Bacteria from Microwell Arrays Using Photodegradable Hydrogel Membranes. ACS Applied Bio Materials, 2 (1): 266-276.
https://pubs.acs.org/doi/pdf/10.1021/acsabm.8b00592
Priscila's CV
Presentations
|
|
